Sharks Killed for Oil Used in Swine Flu Vaccine

Vaccines being made to protect people from swine flu may not be so healthy for threatened species of sharks.

That's because millions of doses of the pandemic H1N1/09 vaccine contain a substance called squalene, which is extracted from shark livers. (Get more swine flu facts.)

More commonly found in beauty products such as skin creams, squalene can be used to make an adjuvant, a compound that boosts the body's immune response.

The World Health Organization recommends adjuvant-based vaccines, because they allow drug makers to create doses that use less of the active component, increasing available supplies.

Olive oil, wheat germ oil, and rice bran oil also naturally contain squalene, albeit in smaller amounts. But for now squalene is primarily harvested from sharks caught by commercial fishers, especially deepwater species. (Related:"Tomato, Tobacco Plants Produce SARS Vaccine.")

"There are several very disturbing issues associated with use of shark-liver-oil squalene," said Mary O'Malley, co-founder of the volunteer-run advocacy group Shark Safe Network.

"The deepwater sharks targeted have extremely low reproductive rates, and many are threatened species."

For example, one supplier has dubbed the gulper shark the Rolls-Royce of squalene-producing sharks—but the gulper is listed as vulnerable on the International Union for Conservation of Nature's (IUCN's) Red List of Threatened Species, meaning the species faces a high risk of extinction.

Shark Oil Demand

Although vaccines containing squalene have not yet been approved for use in the U.S., they are being distributed elsewhere, including Europe and Canada.

Novartis, a drug company that produces swine flu vaccines containing shark squalene, did not answer requests for information about its squalene supply.

GlaxoSmithKline (GSK), another major swine-flu vaccine producer, announced in October that it had received orders for 440 million doses of vaccine containing adjuvant.

And the adjuvant in GSK's vaccines—which have been administered in 26 countries so far—contains shark-liver squalene, company spokesperson Clare Eldred confirmed in a statement.

GSK wouldn't reveal the name of its supplier or the annual quantity of shark squalene it buys. But Eldred told National Geographic News that the drug company takes about 10 percent of its supplier's total output.

O'Malley, of the Shark Safe Network, estimates that GSK's 440 million doses would require at least 9,700 pounds (4,400 kilograms) of shark oil, based on the stated squalene content of 10.69 milligrams in a dose.

This estimate, however, assumes zero waste and no refining of the squalene once it's been extracted from the sharks, O'Malley said.

Slow-Growing Sharks

Found at depths of between 984 and 4,921 feet (300 and 1,500 meters), the deep-sea sharks that produce squalene are most frequently caught via bottom trawling, either deliberately or as bycatch.